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MetaCyc Reaction: 3.2.1.52

Superclasses: Reactions-Classified-By-Conversion-Type Simple-Reactions Chemical-Reactions
Reactions-Classified-By-Substrate Small-Molecule-Reactions

EC Number: 3.2.1.52

Enzymes and Genes:
β-N-acetylhexosaminidase Inferred from experiment : nagZ ( Escherichia coli K-12 substr. MG1655 )
β hexosaminidase S : HEXA ( Homo sapiens )
β-hexosaminidase A Inferred from experiment : HEXA , HEXB ( Homo sapiens )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: β-N-acetylhexosaminidase

Enzyme Commission Synonyms: hexosaminidase, β-acetylaminodeoxyhexosidase, N-acetyl-β-D-hexosaminidase, N-acetyl-β-hexosaminidase, β-hexosaminidase, β-acetylhexosaminidinase, β-D-N-acetylhexosaminidase, β-N-acetyl-D-hexosaminidase, β-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, β-D-hexosaminidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 130.41156 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on N-acetylglucosides and N-acetylgalactosides.

Citations: [Cabezas89, Calvo78, Frohwein67, Li70]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.2.1.52 , ENZYME:EC:3.2.1.52 , IUBMB-ExplorEnz:EC:3.2.1.52 , UniProt:RELATED-TO:P06865 , UniProt:RELATED-TO:P07686 , UniProt:RELATED-TO:P13723 , UniProt:RELATED-TO:P20060 , UniProt:RELATED-TO:P29416 , UniProt:RELATED-TO:P39848 , UniProt:RELATED-TO:Q9CFI2 , UniProt:RELATED-TO:Q9JVT3 , UniProt:RELATED-TO:Q04786 , UniProt:RELATED-TO:Q54468


References

Cabezas89: Cabezas JA (1989). "Some comments on the type references of the official nomenclature (IUB) for beta-N-acetylglucosaminidase, beta-N-acetylhexosaminidase and beta-N-acetylgalactosaminidase." Biochem J 261(3);1059-60. PMID: 2529847

Calvo78: Calvo P, Reglero A, Cabezas JA (1978). "Purification and properties of beta-N-acetylhexosaminidase from the mollusc Helicella ericetorum Muller." Biochem J 175(2);743-50. PMID: 33660

Frohwein67: Frohwein YZ, Gatt S (1967). "Isolation of beta-N-acetylhexosaminidase, beta-N-acetylglucosaminidase, and beta-N-acetylgalactosaminidase from calf brain." Biochemistry 6(9);2775-82. PMID: 6055190

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Li70: Li SC, Li YT (1970). "Studies on the glycosidases of jack bean meal. 3. Crystallization and properties of beta-N-acetylhexosaminidase." J Biol Chem 245(19);5153-60. PMID: 5506280


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 38:D473-D479 2010
Page generated by SRI International Pathway Tools version 18.0 on Wed Aug 27, 2014, biocyc13.